Had esketamine a while ago for depression (supposedly like ketamine but less so) and want an experience like that again. I don’t have a plug so my options are more limited. Is DXM similar enough?

  • insurgentrat [she/her, it/its]@hexbear.net
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    3 months ago

    If you’re interested in trying to treat your depression emerging research indicates that nitrous oxide may have a similar mechanism to ketamine.

    https://www.sciencedirect.com/science/article/abs/pii/S0278584623001550

    Although it would be fiddlier to set up and there’s b12 depletion stuff that iirc isn’t fully mapped out but avoiding chronic use the drug seems very safe. It is also a dissociative anaesthetic, people that get hurt usually aren’t flowing it with oxygen.

    To answer your question about DXM. There is a lot more nausea and vertigo, it is also a dissociative anaesthetic. A much less popular drug, check out the erowid experience vaults. They’re an amazing resource for getting an idea of what to expect.

    • BountifulEggnog [she/her]@hexbear.netOP
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      3 months ago

      Thank you, I’d been meaning to look into nitrous before. Not sure why I hadn’t. I guess part of that is the fiddly-ness of a set up. That study definitely has some good conclusions.

      Obviously treating my depression would be great but a lot of it is just wanting to dissociate/not feel like I’m here for a bit.

      I will check erowid for both, thanks again.

      • Koolio [any]@hexbear.net
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        3 months ago

        Nitrous, at least in the US, famously has never been easier to use / abuse. You can go on Amazon right now and buy a 4 liter tank (which comes with a “cracker” nozzle to dispense)

        Never consume directly from the canister though, that’s how you get throat frostbite or literally blowing your lungs out. A balloon works well, headshops generally sell those thicker punch balloons.

        It’s safer to do a bunch in one session than do it regularly - as stated regular use leads to B12 depletion and neuropathy. Otherwise it is perfectly safe. You would want to supplement before use ideally, as you can not absorb B12 well for a while.

        Safe use is at most one session every 3 - 4 weeks or so, with B12 supplementation.

      • insurgentrat [she/her, it/its]@hexbear.net
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        3 months ago

        No worries, with nitrous it’s easy enough to just inflate a balloon and Huff some. Keep in mind that you cannot detect a lack of oxygen, only co2 build up. Therefore it is possible to deprive yourself of o2 and cause a TIA or pass out, it’s also heavier than air so in a closed room and a long session that can be dangerous.

        I always recommend breathing air alongside, a cheap pulseoximeter from a pharmacy can also tell you when your spO2 is back up to normal for taking another hit.

        If you want to go to space you want an oxygen tank along side a nos tank and to mix the gases into a 20% o2 mix. You can breath that to your hearts content. As with all activities having a mate with you makes it safer. Equipment for that sort of thing is a bit exxy though.

  • Robert_Kennedy_Jr [xe/xem, xey/xem]@hexbear.net
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    3 months ago

    Ehh it’s been a long time since I’ve done either but I had some enjoyable and not so enjoyable experiences with DXM, just be careful how you’re ingesting it, I remember one of the ingredients in Coricidin can affect your heart when taken in quantity, I generally just drank Robotussin DM but that stuff is gross.

    • BountifulEggnog [she/her]@hexbear.netOP
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      3 months ago

      Was planning on getting it from robocough, not really sure what the difference between products is but I will make sure it doesn’t have Coricidin in it. thank you.

      • ClathrateG [none/use name]@hexbear.net
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        3 months ago

        iirc that’s the guaifenesin that’s bad in large quantities(also some formulations contain DPH which is a whole other kettle of fish), there’s a acid/base extraction method know as ‘lemon tek’ you can google to extract the (relatively)pure DXM from other ingredients, not sure if it’d work with a syrup but you can probably search it up

      • Koolio [any]@hexbear.net
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        3 months ago

        Robotabs are pure DXM freebase - if you’re going to try DXM, it’s the safest form. I tried them once, it was an interesting experience, DXM by itself will make you vomit, I also kinda felt fucked up for a couple days after, as a one time thing it was an okay experience - maybe I would try it again, but it was not something I feel a need to do again.

  • Des [she/her, they/them]@hexbear.netM
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    3 months ago

    try it first before committing DXM feels extremely icky so some people at the disassociative doses.

    i basically felt like i had a high fever while under the lower tier effects and i generally take well to most disassociatives.

  • LeylaLove [she/her, love/loves]@hexbear.netM
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    3 months ago

    DXM is prescribed at low doses with Wellbutrin to treat depression. While I can’t speak about it pharmacologically, I can say that DXM definitely helped me see beauty in the world when I normally didn’t.

  • ComradeSharkfucker@lemmy.ml
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    3 months ago

    Banger tbh. Done it maybe 7 ish times and they have all been good but nothing beats the magic of your first. Imo, mix it with acid if you are into that and definitely buy the pills (make sure it is only DXM and not cut) not the liquid. The geometry of it is fantastic and the colors behind my eyes were beautiful. DXM is a vibe just don’t do it often.

    To be clear I have never actually done it with acid but I have always wanted to and everyone who does says it is fantastic.

  • LanyrdSkynrd [comrade/them, any]@hexbear.net
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    3 months ago

    Whatever source you have, make sure it’s just DXM. Coricidin has a high blood pressure version that is only DXM. IMO, it’s the best way to take it at high dose, syrups taste terrible, and DXM will give you stomach discomfort. When I did syrups, I would have nasty syrup tasting burps.

    Every time I’ve done DXM, I pretty violently threw up. If you are doing high dose, just go in expecting to throw up a d you’ll be fine after.

    It’s an interesting substance at high doses, but I probably would never do it again. I’m not sure what the lower dose effects are, if any.