I did this with Qubes a year ago and haven’t had any issues apart from figuring out the right flags to get the full performance, otherwise the GPU would cap around 30% under load with low CPU load.
Kind of at the mercy of what your motherboard and bios will allow, mine I had to cheese a little and disable the PCI device on boot so I get to decrypt my disk with no screen lol but it works!
My brother needed the driver installed in debian on Qubes but has been flawless beyond that. When I was still running arch it just worked out of the box