Regardless of your opinion on whether dude has become genderless or not (I also use dude for my friends of any gender), the word is a gendered term that has become ubiquitous. If someone doesn’t want me to use “dude” referring to them, I won’t. It’s not good to assume, so until I know that someone doesn’t mind, I’m not going to use gendered terms contrary to their gender. I wouldn’t call a man “sis” or “girl” the same way I would women I’m friends with, unless I know that doesn’t make them uncomfortable. I wouldn’t call a woman “bro” or “guy” the same way I would men I’m friends with unless I checked. All of those terms are gender nonspecific for me, but they might make someone who doesn’t have my lived experience uncomfortable.
Apologies! I couldn’t see any pronouns from the image so defaulted to gender nonspecific they. Edited.