You’d be surprised. Check AliExpress. There are aftermarket units built to fit perfectly into every dumb auto fascia they’ve come up with to prevent it. A simple harness adapted is usually sufficient to restore steering wheel controls etc.

I’ve heard of a couple of vehicles where you simply cannot replace the media centre because it doubles as climate control input etc but the simple answer is: refuse to buy those vehicles.

GM Single handedly keeping aftermarket stereos relevant. I wouldn’t buy a car with this solution.

Android auto upgrades with my devices. It’s the best solution.

Nobody uses dropbox because they like dropbox. They use it because it’s usually the only such service supported by the stupid fucking app they need on the stupid fucking ipad their company insists they use which has no other viable way to put files on and off of the fucking cunting thing because apple is fucking stupid and so is this god damn company.

Someone once told the IT manager that apple devices are “the most secure” and he doesn’t even fucking realise that by forcing us to use fucking stupid third party fucking services like fucking dropbox to get files on and off that they are subjecting confidential commercial fucking information to being fucking exposed to third fucking party boneless fucking cunts.

Finished as in they no longer get to be installed on anything in my house. I realise that most people seem to love the taste of shit sandwiches. Not for me.

As soon as streaming services start acting like that, they’re gone. The only one I have left is Netflix, and it is on thin ice - we’ll see what they do with their pricing structure going forward and if they start trying to push ads on higher tiers.

all labor is prostitution

Pleased to meet you, comrade.

Prostitution is a very hard job.

You better be quiet before you summon the bears.

Is an actor paid for their labour? No. They are paid to emote, so that it can be commodified and sold for profit. Human emotion for sale. It’s prostitution.

I’ve been wanting these guys to chill for over 20 years. They have no chill. I’ve read so many takes on what it is they actually want, and why they keep seizing power. It seems the actual answer is that they just want power. Plain and simple.

Acting is emotional prostitution at best, and actual prostitution at worst. If you aren’t comfortable with that, then don’t get in a relationship with an actor. No point burning your relationship down later because you suddenly don’t like the context of that prostitution.

Jonah Hill really is a piece of shit. I’m glad my gut instinct was to fall into a bottomless pit of cringe every time he appears on screen. I could never stand that fat little toad.

That sounds like something that should be illegal. You bought the screen. It belongs to you.

Can you root the TV and be rid of that horrible functionality?

I disagree. I will not under any circumstances be advertised to in my own home.

I’m happy to pay for your goods and services, but if you break that agreement our relationship is immediately concluded. The penalty for breaking the original terms of our agreement is that I will take what I originally paid for in perpetuity. You had your chance.

Same rules apply for attempting to renegotiate the rules whilst the ball is in play: see Amazon’s new trend of attempting to charge an additional monthly fee of the same amount as the initial service to access documentaries etc. They’re finished.

God damn, this comment slaps.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976712/

It’s significant. Biggest effect is on efficacy of drug metabolism. There are many such studies.

One size does not fit all here owing to differences in expression of metabolising enzymes and drug transport mechanisms.

No, the Japanese are not aliens but they may require far less of a given drug than a westerner, or far more. This affects the likelihood to experience side effects for any given compound, and their severity.

It’s fairly ironic to make this change for Japan whilst elsewhere in the world with more racially mixed populations there has been a push in the opposite direction: a recognition that you cannot assume the results of a trial carried out on white male subjects will apply to those of African descent for example.

It’s not just drug treatments either. There are many aspects of medical care which have suffered from a lack of specificity and systemic bias.

I know enough to believe this isn’t a great idea.

Genetic variation in target populations can result in different outcomes for a variety of treatments and is worth testing specifically.

I strongly advocate for the revival of thou! Thou shalt yield.

In a past life I took a bunch of physiology and advanced physiology courses at uni, as well as epidemiology/ population health focused courses and worked with a lot of people on their overall health and fitness. There are so many good reasons to make time for cardio. Ignoring calories for a minute, it has an overwhelmingly positive effect on mental health and wellbeing as well as significantly reducing disability adjusted life years, maintaining balance and strength into old age and reducing the risk and severity of falls as well as a host of cardiovascular diseases.

Heavy cardio also has a startlingly fast positive impact on the visual appearance of your body even in caloric balance, which can go a long way towards keeping you motivated with any dietary changes you may be making.

Having said all that, I find that for those who are just starting their fitness/weight loss journey cardio exercise can set off an absolute rocket of hunger that can potentially undo a lot of good work. I know for me, that hunger after a really hard run can far outweigh the calories I have just burned on that run.

For sedentary individuals just coming to the table, I had way more success in terms of both results and adherence by using programs where the cardio component kicked off with fast paced walking or hill walking for many months before trying to introduce running, swimming or other forms of higher intensity exercise. All of this backed up by a solid resistance training program.

Once you are starting to see concerete progress towards your goals with something as easy as WALKING and a few weights multiple times per week it’s way easier to stay on track once the hunger kicks in after your first few runs.

The battle is real.

If you are aware of this issue, it is your obligation to tell all of your friends, family, associates and coworkers to stop using Chrome immediately, and try out a new search engine.

It’s the least you can do.

This behaviour by Google is not going to stop. The mask has slipped too many times. They have become the very thing they swore to destroy.

Not many people will be ready to de Google their phones and stop buying their products. It’s the little things that will hurt them the most and show they’ve stepped over a line this last year or so.

Most of these guides seem to go like this:

Start with testosterone enanthate powder… right. If I could get hold of that I’d be more than half way there already.