My nominees and some of their top sci-fi roles:
Oscar Isaac:
• Star Wars 7-9 - Poe Dameron
• Dune Part 1 - Duke Leto Atreides
• X-Men Apocalypse - Apocalypse
• MCU (Moon Knight) - all 3 Moon Knight personae
• Spider-Verse movies - Miguel O’Hara (Spider-Man 2099)
Christopher Lloyd:
• Back to the Future I-III - “Doc” Emmet Brown
• Star Trek 3 - Kruge
• Star Wars (The Mandalorian) - Commissioner Helgait
Djimon Honsou:
• MCU films (Guardians of the Galaxy, Captain Marvel) - Korath the Pursuer
• DCEU film (Aquaman) - Fisherman King
• DCEU films (Shazam 1 & 2, Black Adam) - the Wizard Shazam
• Stargate - Horus
Yep, absolutely, it’s not even a contest
Guy played multiple roles in some of the same episodes.